Can caloric restriction supplements mimic fasting? | Dr. Mark Mattson


Scientists have recognized varied bioactive compounds that mimic a number of the methods during which calorie restriction or fasting work. The best-studied of those so-called mimetics embrace resveratrol, a polyphenol present in grapes and wine, and spermidine, a polyamine compound present in cheese and mushrooms. A mimetic that Dr. Mattson has labored with is 2-deoxyglucose – a glucose molecule that lacks a hydroxyl group. 2-deoxyglucose might be taken up in cells similar to glucose is, but it surely can’t be used to provide ATP. Consumption of 2-deoxyglucose mimics the consequences of glucose deprivation. Although some analysis signifies that 2-deoxyglucose is neuroprotective and extends lifespan, it seems to have dangerous results on the cardiovascular system. Dr. Mattson cautions in opposition to counting on mimetics; slightly he recommends exercising, fasting, eating a healthy weight loss plan, and maintaining the mind engaged as one of the best methods for sustaining cognitive health. In this clip, Dr. Mark Mattson discusses the professionals and cons of calorie restriction mimetics.

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Original episode posted Oct 7, 2021.



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