Premature Death and Cardiovascular Disease Linked to High Glycemic Index Eating


September 15, 2021 · 7:00 AM

Naan, a kind of flat bread with a high glycemic index

Haven’t we all know this for years? From New England Journal of Medicine:

Most knowledge concerning the affiliation between the glycemic index and heart problems come from high-income Western populations, with little info from non-Western international locations with low or center incomes. To fill this hole, knowledge are wanted from a big, geographically numerous inhabitants.


This evaluation contains 137,851 contributors between the ages of 35 and 70 years residing on 5 continents, with a median follow-up of 9.5 years. We used country-specific food-frequency questionnaires to decide dietary consumption and estimated the glycemic index and glycemic load on the premise of the consumption of seven classes of carbohydrate meals. We calculated hazard ratios utilizing multivariable Cox frailty fashions. The main end result was a composite of a serious cardiovascular occasion (cardiovascular demise, nonfatal myocardial infarction, stroke, and coronary heart failure) or demise from any trigger.


In the research inhabitants, 8780 deaths and 8252 main cardiovascular occasions occurred throughout the follow-up interval. After performing intensive changes evaluating the bottom and highest glycemic-index quintiles, we discovered {that a} weight-reduction plan with a high glycemic index was related to an elevated danger of a serious cardiovascular occasion or demise, each amongst contributors with preexisting heart problems (hazard ratio, 1.51; 95% confidence interval [CI], 1.25 to 1.82) and amongst these with out such illness (hazard ratio, 1.21; 95% CI, 1.11 to 1.34). Among the parts of the first end result, a high glycemic index was additionally related to an elevated danger of demise from cardiovascular causes. The outcomes with respect to glycemic load have been comparable to the findings concerning the glycemic index among the many contributors with heart problems at baseline, however the affiliation was not vital amongst these with out preexisting heart problems.


In this research, a weight-reduction plan with a high glycemic index was related to an elevated danger of heart problems and demise.

Source: Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality | NEJM

The Advanced Mediterranean Diet (2nd version) is low glycemic index.

Steve Parker, M.D.

front cover of Conquer Diabetes and Prediabetes

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